Featuring over 300 duplicate posters in exceptional condition from the museum's archives, the sale is expected to realise in excess of £500,000.
The money raised will go towards future acquisitions, conservation and restoration of the museum's transport poster and artworks collection, which comprises some 40,500 pieces, making it the world's largest collection in this field.
In 1908 Frank Pick (1878-1941) was given the responsibility for promoting the services of the Underground. He initiated a modern, colourful, poster campaign to encourage off-peak travel, which has been actively continued ever since.
This sale will include a large array of these designs: from pre-War posters advertising the speed and convenience of the Underground to posters about Tube etiquette or those offering advice on how to get to major sporting events at Wimbledon, Wembley or Twickenham.
Posters by some of the biggest names in Underground poster design such as Edward McKnight Kauffer (1890-1945) and Fougasse (1887-1965) will also feature.
Estimates start at £800 and rise to £15,000.