Toula Stefani, 78, discovered the break-in when she returned to her shop, called Stefani Antiques, on Tuesday after the bank holiday.
The police are now appealing to the trade to keep a look out for any of the stolen objects.
Thousands of pounds worth of items were taken including 12 boxes of silver cutlery, rings, tie pins, bracelets as well as a silver postage stamp holder 1883 with penny black stamps inside.
Stefani has traded from the premises since 1982 and worked in the trade for 40 years.
Thieves are believed to have entered the premises by removing tiles from the back roof and gained access by smashing a window between a workshop and the shop.
She said: “I am still in shock but I am determined to try my hardest to get my goods back. I have just turned 78 and am still fully active in my business as I am so passionate about it. I have had burglaries in the past but never as much stock has gone missing as this.
“I was advised by the police to contact people within the antiques network to ask them to be aware that if they are approached to buy a large amount of silver including full sets of knives, cutlery or a variety of jewellery, to let me or the police know.”
Anyone with information should contact the police and quote crime reference number 0517106765.